NFL Week 16 Predictions, Betting Picks & Odds

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NFL Week 16 kicks off with the Saints vs Rams, and we have our best NFL picks for every game this season.

There is plenty of value with NFL betting odds, and the biggest games this week include Bengals vs Steelers, Ravens vs 49ers, and Cowboys vs Dolphins.

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NFL Week 16 Predictions

New Orleans Saints vs Los Angeles Rams @ SoFi Stadium

The Rams are teetering on the edge of the playoffs, so a win over the Saints is needed on Friday.

They have been playing well recently, which is reflected with betting markets, which have them at $1.48 to win.

We’re happy to take the –4.5 line available.

Betting tip: Rams –4.5 @ $1.90

Rams by 7

Cincinnati Bengals vs Pittsburgh Steelers @ Acrisure Stadium

The Bengals have done well without Joe Burrow, and a win over Pittsburgh could be on the cards.

They are the slight favourites at $1.73, which is where we would have priced these even teams.

We’re happy to take the Bengals to win, but it could come down to which team wins the fourth quarter.

Betting tip: Bengals @ $1.73

Bengals by 3

Buffalo Bills vs Los Angeles Chargers @ SoFi Stadium

The Bills have made an almighty charge towards the playoffs, and the Chargers are without their best player.

Not having Justin Herbert is enough for the Bills to be the $1.17 favourite, which isn’t shocking given their recent form.

The current line is –12.5, and we’re taking that line before it potentially moves.

Betting tip: Bills –12.5 @ $1.90

Bills by 14

Indianapolis Colts vs Atlanta Falcons @ Mercedes-Benz Stadium

The Falcons blew a chance to make the playoffs last week, and the Colts could capitalise this week.

The Colts improved to 8-6 with another gutsy win, which is an excellent form guide for this important game.

Take the Colts to win at $1.92, which is a fair price against a Falcons team who could struggle to recover.

Betting tip: Colts @ $1.92

Colts by 6

Seattle Seahawks vs Tennessee Titans @ Nissan Stadium

There is still hope for the Seahawks, who should have a good chance of beating the 5-9 Titans.

They are only 2-5 on the road, so that’s a concern, but the Seahawks have a solid enough team to make a playoff push.

Getting $1.70 for the better team is worth entertaining.

Betting tip: Seahawks @ $1.70

Seahawks by 7

Detroit Lions vs Minnesota Vikings @ U.S. Bank Stadium

The Lions got back to their best when winning last week, and they’re looking to knock the Vikings out of the playoff equation.

It’s never easy to trust the Lions, but they are a better team in 2023, so we’re happy to trust them in this situation.

Getting $1.62 for the Lions, despite playing on the road, is a fair price.

Betting tip: Lions @ $1.62

Lions by 7

Washington Commanders vs New York Jets @ MetLife Stadium

There isn’t much to get excited about for this game, but we’re including the Jets in our NFL multis.

They are only 5-9, but they’re better than the Commanders, and the Jets defence is good enough to keep them in the game.

It won’t be a heavily wagered game on Monday.

Betting tip: Jets @ $1.62

Jets by 6

Green Bay Packers vs Carolina Panthers @ Bank of America Stadium

The Panthers pulled off an upset last week, giving them just their second win of the year.

The Packers are the better team, which is why they’re the $1.46 favourites to improve to 7-8.

Bookmakers have the line at –5.5 for the Packers, and we’re happy enough to include that option in our NFL picks.

Betting tip: Packers –5.5 @ $1.90

Packers by 7

Cleveland Browns vs Houston Texans @ NRG Stadium

There won’t be much between the Browns and Texans, but with home ground advantage, we’re taking the Texans to win.

C.J. Stroud has cooled off a touch, but he’s still a quality quarterback in the making, throwing 20 touchdowns and only five interceptions.

He’s good enough to lead the Texans to a crucial victory over the Browns.

Betting tip: Texans @ $1.73

Texans by 7

Jacksonville Jaguars vs Tampa Bay Buccaneers @ Raymond James Stadium

There is nothing splitting the Jaguars and Buccaneers with bookmakers, and it’s a tricky game to sort out.

The Jaguars are a much better team on the road, with a 5-1 record, which could be enough to see them take down the Buccs.

It’s not a confident bet but take the Jaguars to prevail in a close game.

Betting tip: Jaguars @ $1.90

Jaguars by 4

Arizona Cardinals vs Chicago Bears @ Soldier Field

There won’t be much betting interest with the Cardinals vs Bears.

Chicago is 5-9 and playing at home, which gives it the advantage over the 3-11 Cardinals, who can play well at times.

Include the Bears in NFL multis, but it’s not our most confident bet.

Betting tip: Bears @ $1.48

Bears by 3

Dallas Cowboys vs Miami Dolphins @ Hard Rock Stadium

The closer the Cowboys get to the playoffs, the worse they typically play.

That has been the case this season, but they’re still a quality team at 10-4, and they looked good beating the Eagles, who are going backwards.

Miami is tough to beat, especially on offence. With a 6-1 home record, we’re backing the Dolphins to come out ahead.

Betting tip: Dolphins @ $1.85

Dolphins by 7

New England Patriots vs Denver Broncos @ Empower Field

Denver has a great chance to make a playoff push with a win over the Patriots.

The Broncos are 7-7, and the Patriots have been relatively awful this year, so it should be an easy win.

They are –6.5 favourites, so punters get them at less than a touchdown, and we can’t turn down those odds.

Betting tip: Broncos –6.5 @ $1.90

Broncos by 7

Las Vegas Raiders vs Kansas City Chiefs @ GEHA Field

The Chiefs are –10.5 favourites, which is a fair line given what’s at stake.

There is more reason for the Chiefs wanting to perform, and the Raiders are only out to make life difficult for the defending NFL champions.

They’re not at their best, but the Chiefs have the class edge.

Betting tip: Chiefs –10.5 @ $1.90

Chiefs by 14

New York Giants vs Philadelphia Eagles @ Lincoln Financial Field

The Eagles are sliding down the ranking after losing four on the bounce, which is a massive concern.

However, they play the Giants at the right time, and punters should expect a one-sided affair on Tuesday.

A win is needed for their confidence, and it should be an easy victory.

Betting tip: Eagles –11.5 @ $1.90

Eagles by 14

Baltimore Ravens vs San Francisco 49ers @ Levi’s Stadium

We like what the 49ers are doing, and they look Super Bowl ready.

They are 11-3, and Christian McCaffery is a beast at the running back position, and he could be the difference.

Getting a –5.5 line is generous, despite playing against a dangerous Ravens outfit.

Betting tip: 49ers –5.5 @ $1.90

49ers by 10

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About Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism. Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. Coupled with his love of US sport, Daryl's picks have been featured on various websites around the world and viewed by millions of readers. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NBA, NFL, and college sports. When he's not working, Daryl tries to avoid making bogeys on the golf course.