NFL Week 10 Predictions, Betting Picks & Odds

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NFL Week 10 continues this week with a stack of games, and we have our best NFL picks for every game this season.

There is plenty of value with NFL betting odds, and the biggest games this week include Saints vs Vikings, 49ers vs Jaguars, and Broncos vs Bills.

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NFL Week 10 Predictions

Carolina Panthers vs Chicago Bears @ Soldier Field

The Panthers have only one time to their name, but the Bears haven’t been much better with two wins.

The Bears are favoured with bookmakers at $1.55, which isn’t surprising. They are at home, and the Panthers haven’t had much go their way.

Take the home side to prevail.

Betting tip: Bears @ $1.55

Bears by 3

Indianapolis Colts vs New England Patriots @ Frankfurt Stadium

We’re not sure what’s going wrong with the Patriots but backing them has been costly.

There is much more momentum with the Colts, and playing on neutral ground in Germany won’t do their chances any harm.

We’re locking in the Colts to win.

Betting tip: Colts @ $1.77

Colts by 7

Houston Texans vs Cincinnati Bengals @ Paycor Stadium

The Texans, and most importantly, C.J. Stroud, are playing well, but they run into the Bengals on Monday.

Cincinnati is one of the hottest teams in the NFL, and most expect them to take care of the visiting Texans.

We respect the Texans, but the Bengals have Super Bowl ambitions.

Betting tip: Bengals –6.5 @ $1.83

Bengals by 7

New Orleans Saints vs Minnesota Vikings @ U.S. Bank Stadium

The Vikings are having injury problems, which leads us to believe the Saints will get it done.

They are 5-4, so having a winning record should give them enough confidence to win on the road in a tough environment.

Without Kirk Cousins, the Vikings could struggle.

Betting tip: Saints @ $1.67

Saints by 6

Green Bay Packers vs Pittsburgh Steelers @ Acrisure Stadium

The Packers fought bravely last week, but we expect the Steelers to be too strong at home.

They are always tough to beat at home, and although their 3-2 home record isn’t overly exciting, they have lost some close ones.

The current line is –3.5, which is always a tricky line. However, we’re taking Pittsburgh to win by a touchdown.

Betting tip: Steelers –3.5 @ $1.96

Steelers by 7

Tennessee Titans vs Tampa Bay Buccaneers @ Raymond James Stadium

There isn’t much between the Titans and Buccaneers in betting markets, and the stats are also similar.

The Titans and Buccaneers have 3-5 records, but the Titans have never won on the road, which is the biggest concern.

Tampa Bay is a $1.85 favourite, so that’s a good enough price to take.

Betting tip: Buccaneers @ $1.85

Buccaneers by 3

San Francisco 49ers vs Jacksonville Jaguars @ EverBank Stadium

It’s the biggest game of the week as the Jaguars look to one-up the former Super Bowl favourites.

Things started well for the 49ers, but recent losses and injuries have seen them fall to 5-3. However, the Jaguars are rolling at 6-2.

We think the home side is good enough to pull off the upset and send the 49ers spiraling.

Betting tip: Jaguars @ $2.30

Jaguars by 7

Cleveland Browns vs Baltimore Ravens @ M&T Bank Stadium

The Ravens flexed their muscles against the Seahawks last week, scoring one of the more impressive wins of the year.

Backing it up won’t be easy, but Lamar Jackson is playing with great confidence, and we’re backing them to win again.

The –6.5 line might not last long.

Betting tip: Ravens –6.5 @ $1.90

Ravens by 10

Atlanta Falcons vs Arizona Cardinals @ State Farm Stadium

The Cardinals have beaten the Dallas Cowboys, but that’s their only win of the season.

Atlanta fell to 4-5 last week, but the Falcons have much more upside, so we’re backing them to win at the generous odds.

Punters never know what to expect from the Cards, but they’re playing for a draft pick.

Betting tip: Falcons @ $1.77

Falcons by 6

Detroit Lions vs Los Angeles Chargers @ SoFi Stadium

We like what the Lions are achieving, and they should be ready to fire against a tricky Chargers outfit.

The Chargers are in danger of falling behind .500, but they usually hover around an even win/loss record.

The Lions are 6-2, so we’re backing them to win.

Betting tip: Lions –3.5 @ $2.02

Lions by 7

New York Giants vs Dallas Cowboys @ AT&T Stadium

The Cowboys are the biggest favourites of the week at –15.5, which is a sizable line.

However, the Giants aren’t doing enough to impress anyone, and the Cowboys are seemingly back to their best, despite losing to the Eagles.

A big win should be on the cards.

Betting tip: Cowboys –15.5 @ $1.90

Cowboys by 21

Washington Commanders vs Seattle Seahawks @ Lumen Field

The Seahawks couldn’t have been any worse last week, but that was against the norm.

We expect them to bounce back against the 4-5 Commanders, especially with the benefit of playing at home.

With a 3-1 record at Lumen Field, the Seahawks should be too good.

Betting tip: Seahawks –6.5 @ $1.90

Seahawks by 10

New York Jets vs Las Vegas Raiders @ Allegiant Stadium

The Jets have a good defence, which is often enough to win NFL games.

Bookmakers have them at $1.91 to beat the Raiders, who haven’t been overly impressive, so we’re backing a Jets win.

Improving to 5-4 with a second-string quarterback would be some effort.

Betting tip: Jets @ $1.91

Jets by 4

Denver Broncos vs Buffalo Bills @ Highmark Stadium

The Bills haven’t looked amazing so far, but they’re doing enough to be in the playoff hunt.

Bookmakers have the line at –7.5 against the Broncos, which is a fair line against a team like the Broncos, who are only moderate.

Playing at home is big for the Bills.

Betting tip: Bills –7.5 @ $1.90

Bills by 10

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About Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism. Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. Coupled with his love of US sport, Daryl's picks have been featured on various websites around the world and viewed by millions of readers. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NBA, NFL, and college sports. When he's not working, Daryl tries to avoid making bogeys on the golf course.